Alex Cox presents a story that can only be set in Loserville. Deke and Jenna are a happily married couple working their way through life until something unexpected changes their lives. Deke has ambitions, he wants to be either a novelist, or screenwriter, or artist, or professional wrestler. He can't decide which, all he knows is he doesn't like working at an insurance company. 

Jenna, on the other hand, is a workaholic. While Deke is not sure what it is that Jenna does, he does know that she complains about it — a lot. Jenna also complains about having hot feet and that she might have the worst disease in the world: Multiple Sploderorsis. A disease that dooms you to a life of crippling pain... and then you might explode! Not very many people have it, because they all explode. 

Now Deke and Jenna are faced with the challenges of knowing that she might explode at any minute. Because sometimes that's just the way these stories go.

Issue #1 introduces us to our intrepid couple and shows a slice of their personal lives and how they relate to each other and the rest of the world.