News magazine "In Focus" covers Monk's handling of a serial killer case (in which four people were killed) and the gang gathers for a viewing party to watch the piece. As Monk watches the interviews of his closest friends and adversaries, he realizes that something about the case leaves him unsettled. John Turturro, Eric McCormack, Sarah Silverman, Howie Mandel, Andy Richter, Brooke Adams and Angela Kinsey guest star in "Mr. Monk's 100th Episode"