As Cathy (Laura Linney) is uncomfortable with the sympathy she receives upon returning to work, she uses her appointment with Dr. Sherman (guest star Alan Alda) to press for a spot in a new clinical trial. Meanwhile, as Sean (John B. Hickey) remains upset over being kept in the dark about his sister's cancer, Rebecca's (Cynthia Nixon) ultrasound prompts her to ask Cathy to throw her a baby shower right away.