Jack, Will, and the Team are called in to investigate a truly disturbing scene—two victims with the skin on their backs cut and tied to the ceiling to mimic angel wings. The killer suffers from a brain tumor, and as more victims surface, Hannibal hypothesizes the tumor is causing violent hallucinations; perhaps he isn't creating his “angels” as symbols of worship but rather as figures of protection. The question is, protection from what? As the hunt continues, Jack must juggle the investigation with the realization that his wife has terminal cancer.